Beilstein J. Org. Chem.2012,8, 2060–2066, doi:10.3762/bjoc.8.231
; fluorinatednaturalproductanalogues; structure-activity relationship; Introduction
Cryptophycins form a class of cytotoxic sixteen-membered macrocyclic depsipeptides. Cryptophycin-1 (1) was isolated for the first time in 1990 from cyanobacteria Nostoc sp. ATCC 53789 [1] (Figure 1). Moore et al. isolated
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Graphical Abstract
Figure 1:
Structures of cryptophycin-1 (1) and -52 (2).